The depressing effect that reading some biographies can have on impressionable readers has been mentioned in several articles, in this one about balancing the books for example.
Too much reading about people whose lives were mostly one long nightmare scenario and who seemed to be under a curse or evil spell can make us feel that we too are trapped in hell with no way out.
Carole Angier's Jean Rhys: Life and Work is the worst of the depressing biographies that I have read to date.
Something that the novelist Rebecca West said about Jean Rhys's autobiographical book After Leaving Mr Mackenzie (1931) also applies to Jean Rhys's other books and to Carole Angier's biography - not to mention many other biographies and fictional works mentioned on here:
“It is doubtful if one ought to open this volume unless one is happily married, immensely rich, and in robust health; for if one is not entirely free from misery when one opens the book one will be at the suicide point long before one closes it.”
This is exactly what I am talking about. Some books have an effect similar to that of the Dementors in Harry Potter!
In addition to being overwhelmed by a general miasma of misery, readers may find some of the material acutely distressing: the details of the suffering that Jean Rhys's actions and lack of coping ability caused to others are very painful to read. The death from pneumonia of the tiny baby she put near a balcony door in the heart of winter, her physical violence against her husbands and the neglect of her dying third husband, who went unwashed and unfed, are some of the worst examples.
An important point here is that it may be even worse for readers for whom some of it comes very close to home.